Comparative Study of Native or Nano Quercetin on Epigenetic Modification and Nephropathy Biomarkers Post Challenges in Diabetic Hamsters

Nassar, Soha Shebel and Sadek, Mona Ahmed and Ismail, Huda Mohamed and Moram, Gehan Salah El-Din (2021) Comparative Study of Native or Nano Quercetin on Epigenetic Modification and Nephropathy Biomarkers Post Challenges in Diabetic Hamsters. Journal of Pharmaceutical Research International, 33 (33B). pp. 140-153. ISSN 2456-9119

[thumbnail of 2634-Article Text-4313-1-10-20221006.pdf] Text
2634-Article Text-4313-1-10-20221006.pdf - Published Version

Download (551kB)

Abstract

Aims: The aim of this study is to examine the regulatory effects of quercetin nanoparticles (QNPs) compared with native quercetin either with or without metformin against the abnormal molecular and biochemical pathways that eventually culminate in the pathologic condition clinically known as diabetic nephropathy (DN) in hamsters

Methodology: After synthesis and characterization of the QNPs, seventy male adult hamsters are divided as following; G1:healthy control, G2:untreated DN hamsters, G3:DN+metformin G4:DN+native quercetin, G5:DN+QNPs, G6:DN+native quercetin+ metformin and G7: DN + QNPs + metformin.

Results: Our results illustrated that the effect of QNPs + metformin is the most effective in IRS-1 and GLUT-4 gene expression that correlated with inhibition of HDACs which in turn improved diabetic and nephropathy biomarkers, this effectiveness followed by G6 then G3 and finally G4 after G5. These results were confirmed by immunohistochemical examinations. Levels of antioxidant and inflammatory biomarkers also reflected the protective effect of our treatments.

Conclusion: All tested treatments significantly exhibit renal improvement.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 24 Feb 2023 05:54
Last Modified: 24 May 2024 05:32
URI: http://repository.journal4submission.com/id/eprint/1014

Actions (login required)

View Item
View Item