Coronary Embolization and Myocardial Microinfarction: MR Imaging and Histopathologic Characterization

Saeed, Maythem and W. Hetts, Steven and Liang, Anqi and Wilson, Mark W. (2016) Coronary Embolization and Myocardial Microinfarction: MR Imaging and Histopathologic Characterization. International Journal of Clinical Medicine, 07 (06). pp. 399-418. ISSN 2158-284X

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Abstract

Magnetic resonance imaging (MRI) has been proven to reliably assess regional perfusion and left ventricular (LV) function of microembolized myocardium. The visibility of microinfarct on delayed enhancement MRI (DE-MRI) is limited and dependent on technical and biological issues. Furthermore, MRI underestimates total microinfarct size compared with microscopy. MRI studies revealed that the presence of microemboli in pre-existing acute infarct delays infarct healing and magnifies LV remodeling. Discrimination of acute from chronic microinfarct is based on presence of inflammatory cells, edema and scar tissue, respectively. These noninvasive findings highlight the importance of prognostic utility of MRI and warrant larger clinical studies or registries to evaluate the significance of presence of focal microinfarct. Serial microscopic studies revealed that intravascular microemboli migrate into the extravascular space and this migration process is a function of time. This phenomenon may limit the use of microemboli therapy in occluding hemorrhagic blood vessels or treating tumors. Despite current standard of care, existing methods and therapies do not prevent coronary embolization nor reverse their deleterious effects.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 25 Jan 2023 05:40
Last Modified: 31 Jul 2024 12:23
URI: http://repository.journal4submission.com/id/eprint/1145

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