Mehta, Preeti P. and Ozarde, Yogita and Gadhave, Ranjit and Swami, Arti (2021) Selective Optimization of Side Activities (SOSA) as an Efficient Approach for Generation of New Leads from Old Drugs. Journal of Pharmaceutical Research International, 33 (42B). pp. 287-297. ISSN 2456-9119
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Abstract
The selective optimization of side activities (SOSA) approach appears to be a promising strategy for lead generation. In this approach old drugs are used to generate new hits or leads. The objective of SOSA is to prepare analogues of the hit molecule in order to transform the observed “side activity” into the main effect and to strongly reduce or abolish the initial pharmacological activity. The idea of taking a molecule with a primary activity in humans and then enhancing a secondary effect through structural changes describes the most common implementation of SOSA. An advantage to starting a drug discovery program with molecules that have already been tested in humans is that those molecules have already satisfied many safety criteria. Such molecules also likely have favourable pharmacokinetic profiles. In the present review different successful examples of SOSA switches are summarized. We hope that the present review will be useful for scientists working in the area of drug design and discovery.
Item Type: | Article |
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Subjects: | Journal Eprints > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 10 Apr 2023 05:00 |
Last Modified: | 17 May 2024 09:39 |
URI: | http://repository.journal4submission.com/id/eprint/1493 |