The Role of Mitochondrial Energetics and Inflammasome NLRP3 in Diabetic Cardiomyopathy

Almas, Maha and Tahir, Usaal and Zameer, Mariam and Mazhar, Maham and Ali, Qurban and Rafique, Ayesha and Khan, Khushbukhat (2021) The Role of Mitochondrial Energetics and Inflammasome NLRP3 in Diabetic Cardiomyopathy. Journal of Pharmaceutical Research International, 33 (42B). pp. 309-315. ISSN 2456-9119

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Abstract

Diabetic Cardiomyopathy is the worldwide leading cause of lethal heart disorders burdening the healthcare systems. Mitochondrion is the key regulator of myocardial metabolism. It fuels the cardiocytes and regulates the pumping activity of heart. People living with diabetes have defected myocardial metabolism which may likely to cause ventricular dysfunction or other heart disorders due to mitochondrial DNA (mtDNA) mutation. Furthermore, the inflammatory injury due to inflammasome activation is a potent contributor to the cardiac injuries. Though the mechanism of inflammation is still poorly known. This review highlights the association of altered mitochondrial energetics and inflammasome activation with cardiomyopathies.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 15 Apr 2023 07:25
Last Modified: 29 Feb 2024 04:16
URI: http://repository.journal4submission.com/id/eprint/1495

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