The immune microenvironment and tissue engineering strategies for spinal cord regeneration

Feng, Yuan and Peng, Yong and Jie, Jing and Yang, Yumin and Yang, Pengxiang (2022) The immune microenvironment and tissue engineering strategies for spinal cord regeneration. Frontiers in Cellular Neuroscience, 16. ISSN 1662-5102

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Abstract

Regeneration of neural tissue is limited following spinal cord injury (SCI). Successful regeneration of injured nerves requires the intrinsic regenerative capability of the neurons and a suitable microenvironment. However, the local microenvironment is damaged, including insufficient intraneural vascularization, prolonged immune responses, overactive immune responses, dysregulated bioenergetic metabolism and terminated bioelectrical conduction. Among them, the immune microenvironment formed by immune cells and cytokines plays a dual role in inflammation and regeneration. Few studies have focused on the role of the immune microenvironment in spinal cord regeneration. Here, we summarize those findings involving various immune cells (neutrophils, monocytes, microglia and T lymphocytes) after SCI. The pathological changes that occur in the local microenvironment and the function of immune cells are described. We also summarize and discuss the current strategies for treating SCI with tissue-engineered biomaterials from the perspective of the immune microenvironment.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 28 Mar 2023 12:13
Last Modified: 23 Mar 2024 04:20
URI: http://repository.journal4submission.com/id/eprint/1685

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