Carbonic Anhydrase Inhibition Affect Antioxidant Enzyme Activity in the Blood of STZ Induced Diabetic Rats

Background: Carbonic anhydrase is found in the blood of all vertebrate and thus playing a fundamental role in the maintenance of acid-base homeostasis. Erythrocytes are intrinsically prone to oxidative stress because of their exposure to high oxygen tension.

Aim: The study aimed to investigate the changes of erythrocytes anti-oxidative enzymes in STZ induced diabetic rats and to determine the antioxidant potential of Cadaba farinosa leaves.

Results: The result of the present study showed that inhibition of carbonic anhydrase result in significant decrease in both erythrocyte and plasma catalase activity, whereas erythrocyte and plasma superoxide dismutase activity increased.

Conclusion: Carbonic anhydrase inhibition may alter the activity of anti-oxidative enzymes in vivo.