Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

Jia, Jia and Cheng, Jian and Wang, Cheng and Zhen, Xuechu (2018) Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases. Frontiers in Cellular Neuroscience, 12. ISSN 1662-5102

[thumbnail of pubmed-zip/versions/1/package-entries/fncel-12-00314/fncel-12-00314.pdf] Text
pubmed-zip/versions/1/package-entries/fncel-12-00314/fncel-12-00314.pdf - Published Version

Download (983kB)

Abstract

A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous system (CNS). In addition to neurons, both cerebral microglia and astrocytes express Sig-1Rs. Activation of Sig-1Rs is known to elicit potent neuroprotective effects and promote neuronal survival via multiple mechanisms, including promoting mitochondrial functions, decreasing oxidative stress and regulating neuroimmnological functions. In this review article, we focus on the emerging role of Sig-1Rs in regulating neuroinflammation and discuss the recent advances on the Sig-1R-modulating neuroinflammation in the pathophysiology and therapy of neurodegenerative disorders.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 01 Jun 2023 06:30
Last Modified: 10 Jan 2024 04:02
URI: http://repository.journal4submission.com/id/eprint/2140

Actions (login required)

View Item
View Item