Hepatoprotective Activity of Holostemma ada Kodien shcult, Extract against Paracetamol Induced Hepatic Damage in Rats

Aim: To study the hepatoprotective activity of alcoholic extract of Holostemma ada Kodien Shcult against paracetamol (PCM) induced liver damage in rats.

Place and Duration of Study: Department of pharmaceutical chemistry and department of pharmacology Geethanjali College of Pharmacy, Cherryal, Keesara, Ranga Reddy District, Andhra Pradesh, India during June 2012 and Jan 2014.

Methods: Hepatotoxicity was induced by paracetamol (PCM) and various biochemical parameters were assessed to confirm the induced degrees of hepatoprotoxicity. The various extracts were tested on animals and various biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and total serum bilirubin (SB) were investigated the hepatoprotective activity was also confirmed by histopathological studies of normal and hepatodamage and post treatment studies with the extract.

The Results: Pre-treatment of the rats with alcoholic extract prior to paracetamol (PCM) administration caused a significant reduction in the values of AST, ALT, ALP and SB (p<0.01) approximately comparable to the hepatoprotective of standard drug was silymarin and confirmed by histopathological examination of the liver tissue of control and treated animals.

Conclusion: From the results it can be concluded that Holostemma ada Kodien Shcult possesses the hepatoprotective effect against paracetamol (PCM) induced liver damage in rats.