Stromal Protein-Mediated Immune Regulation in Digestive Cancers

Gamradt, Pia and De La Fouchardière, Christelle and Hennino, Ana (2021) Stromal Protein-Mediated Immune Regulation in Digestive Cancers. Cancers, 13 (1). p. 146. ISSN 2072-6694

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Abstract

The stromal tumor microenvironment (TME) consists of immune cells, vascular and neural structures, cancer-associated fibroblasts (CAFs), as well as extracellular matrix (ECM), and favors immune escape mechanisms promoting the initiation and progression of digestive cancers. Numerous ECM proteins released by stromal and tumor cells are crucial in providing physical rigidity to the TME, though they are also key regulators of the immune response against cancer cells by interacting directly with immune cells or engaging with immune regulatory molecules. Here, we discuss current knowledge of stromal proteins in digestive cancers including pancreatic cancer, colorectal cancer, and gastric cancer, focusing on their functions in inhibiting tumor immunity and enabling drug resistance. Moreover, we will discuss the implication of stromal proteins as therapeutic targets to unleash efficient immunotherapy-based treatments.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 23 Dec 2022 04:19
Last Modified: 23 Feb 2024 03:47
URI: http://repository.journal4submission.com/id/eprint/225

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