Influenza, SARS-CoV-2, Titin, and Sudden Unexpected Deaths: On the Risk of Multiple Vaccinations

Objective of this short review is to recall data that connect Influenza virus, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), and the human cardiac Titin protein to sudden unexpected deaths (SUDs) through molecular mimicry. Indeed, a direct causality between Influenza virus and SUDs has been repeatedly reported in clinical literature and, more recently, also SARS-CoV-2 vaccination has been related to an alarming incidence of SUDs. Hence, it is of relevance to highlight that Influenza virus and SARS-CoV-2 antigens, i.e., hemagglutinin and spike glycoprotein (gp), share immune determinants with the SUD-related Titin. Such a peptide sharing and the consequent autoimmune cross-reactivity are even more significant since might enable an exponential implementation of SUD events following simultaneous multiple anti-influenza and anti-SARS-CoV-2 vaccinations. On the whole, this possibility imposes caution and careful vaccination clinical trials.