New Case Report on Punctal Stenosis -A Rare Complication of Dupilumab Therapy for Atopic Dermatitis

Abdulwahhab, Waqas S. and Alamiri, Fatima Ibrahim and Mehair, Alaa S. and Qaderi, Fatma Abdulghaffar (2022) New Case Report on Punctal Stenosis -A Rare Complication of Dupilumab Therapy for Atopic Dermatitis. In: New Horizons in Medicine and Medical Research Vol. 7. B P International, pp. 40-45. ISBN 978-93-5547-631-9

Full text not available from this repository.

Abstract

Background: Dupilumab is a biological medication that has been approved for the treatment of moderate to severe atopic dermatitis (AD) and has shown to have a significant therapeutic effect and ability to improve quality of life in clinical trials. Upper respiratory tract infection, headache, nasopharyngitis, injection-site reaction, herpes viral infection, and conjunctivitis were the most common side effects of dupilumab therapy. Dupilumab-induced lacrimal duct obstruction, also known as punctal stenosis, is a seldom observed and poorly researched side effect of the drug.

Aim: To introduce a new case of a young female with a history of AD but no prior significant ocular manifestations who developed right eye punctal stenosis while on Dupilumab therapy for one year.

Case Report: A 19-year-old female with a long-standing history of AD who developed severe punctal stenosis and continued tearing from her right eye in the last two months and was on dupilumab therapy for a year did not respond to conservative ophthalmological drugs, but completely improved after discontinuing dupilumab injection over a 6-month follow-up period.

Conclusions: Conjunctivitis is a well-known side effect of Dupilumab injections in AD disease patients. However, if conjunctivitis and weeping from the eye do not improve after ophthalmology treatment, punctal stenosis may be ruled out, and dupilumab should be stopped.

Item Type: Book Section
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 13 Oct 2023 04:06
Last Modified: 13 Oct 2023 04:06
URI: http://repository.journal4submission.com/id/eprint/2793

Actions (login required)

View Item
View Item