Laplace Pressure Controls Cell Blebbing to Regulate the Symmetry of Cell Division

The Laplace pressure is one of the most fundamental regulators that determine cell shape and function, and as a result, it has gotten a lot of attention.The objective of this study is to systemically investigate the effect of the Laplace pressure on the shape and function of the cells during cytokinesis. We discovered that the Laplace pressure during cytokinesis can directly control the distribution and size of cell blebbing, as well as adjust the symmetry of cell division by changing cell blebbing characteristics. Furthermore, we show that the Laplace pressure alters the structural uniformity of the cell boundary in order to regulate the symmetry of cell division. Our findings provide further insights as to the important role of the Laplace pressure in regulating the symmetry of cell division during cytokinesis.