Study on Procalcitonin as a Prognostic Indicator and as an Early Biomarker in Grading of Sepsis

Aims and Objectives: To investigate the pattern of PCT elevation in sepsis.To see if PCT rises earlier in severe infections than other sepsis indicators. To see if PCT levels may be used to grade sepsis severity. To examine if the rise and fall of PCT levels has any bearing on prognosis. Introduction: PCT is a very good biomarker of sepsis. PCT (Procalcitonin) is a new biomarker that is being utilised to diagnose and grade bacterial sepsis all over the world.PCT distinguishes between infectious and non-infectious disorders and aids in sepsis and septic shock prognosis.

Materials and Methods: The study included 100 patients admitted to medical or surgical departments. The PCT was calculated, as well as other sepsis markers, and the results were compared. The severity of sepsis was graded based on clinical criteria as well as PCT levels.

Observations: PCT values associated well with the degree of sepsis in the entire sample, with a median of 8.89 ng/ml. Normal PCT levels were detected in 24 patients, while very high PCT values were noted in 4 patients.PCT levels more than 7 ng/ml were linked to a higher risk of death. When compared to Gram positive sepsis, Gram negative sepsis showed higher PCT values. Consistently rising PCT readings suggested that sepsis severity was greater, as well as a high fatality rate in this class.

Conclusions: PCT is a sepsis biomarker that can be detected early.In severe sepsis, PCT can be utilised as a prognostic indicator.PCT is an excellent measure for grading sepsis and other clinical characteristics.