Reporting the Usage of Platelet Rich Plasma (PRP) in the Treatment of Acute Post Intubation Tracheal Rupture in Two Cases

The use of PRP involves a complex network of molecular events which accelerate tissue regeneration
due to its richness in growth factors plus a variety of biologic mediators. The authors have presented
their successful experience of its use in pneumology when treating severe hemoptysis, respiratory
fistulae, spontaneous pneumothorax and one tracheal rupture. In this article we present two cases of
post intubation tracheal rupture successfully treated with the local instillation of PRP on one of them
and with the injection of PRP along the lips of the tracheal wound on the other. Tracheal rupture is a
rare but life threatening complication of emergency intubation requiring an effective response in order
to avoid the risk of patient death due to secondary mediastinitis and sepsis. The use of local
autologous PRP in our experience has demonstrated a favorable performance in such cases, turning
it in a highly promising tool for the treatment of conditions such as this, in which a rapidly effective and
minimally invasive handling is required.