Melanogenesis and Melasma Treatment

Maddaleno, Adriana Solange and Camargo, Judit and Mitjans, Montserrat and Vinardell, Maria Pilar (2021) Melanogenesis and Melasma Treatment. Cosmetics, 8 (3). p. 82. ISSN 2079-9284

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Abstract

Melanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in subcellular lysosome-like organelles called melanosomes, where melanin is synthesised and stored. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair, and eyes of mammals. The regulation of melanogenesis includes various mechanisms and factors including genetic, environmental, and endocrine factors. Knowledge of the pigmentation process is important not only to understand hyperpigmentation but also to design treatments and therapies to treat them. Whitening cosmetics with anti-melanogenesis activity are very popular. In the present manuscript, we review the mechanisms and the signalling pathways involved in skin pigmentation and we specifically focus on the alteration of melanogenesis that leads to melasma and results in hyperpigmentation. Finally, current therapies and treatments including topical, oral, and phototherapies are discussed and described, with a special emphasis on the cosmetics’ action.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 28 Nov 2022 06:49
Last Modified: 26 Dec 2023 04:46
URI: http://repository.journal4submission.com/id/eprint/315

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