The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent

Mahendra, Camille Keisha and Tan, Loh Teng Hern and Mahendra, Cayvern Kishen and Ser, Hooi-Leng and Pusparajah, Priyia and Htar, Thet Thet and Chuah, Lay-Hong and Yap, Wei Hsum and Tang, Siah Ying and Ming, Long Chiau and Yow, Yoon-Yen and Goh, Bey Hing (2021) The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent. Cosmetics, 8 (3). p. 79. ISSN 2079-9284

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Abstract

There are many extrinsic factors that can contribute to the premature aging of the skin. In recent years, the demand for natural cosmetic from the general population has noticeable grow. Therefore, this research aimed to investigate the bioproperties of sky fruit (Swietenia macrophylla) seed extract that could help to inhibit premature skin aging. Firstly, the extract and its fractions were tested on HaCaT cells for their wound healing properties. The presence of sky fruit’s extract and its fractions on scratch wound significantly improved cellular proliferation, migration, and closure of the wound. These effects were distinctly observed following the treatment with S. macrophylla hexane fraction (SMHF) and S. macrophylla water fraction (SMWF). Our continuous research study revealed that SMWF had antioxidant properties, which might be one of the factors contributing to its emerging wound healing properties because antioxidants are known to act as suppressors of the inflammatory pathway and aid the transition towards cell proliferation. In addition, all samples had critical wavelengths that indicated that they were able to absorb the whole UVB range and some parts of the UVA wavelength. This suggested that S. macrophylla might contain potential photoprotective bioactive compounds, which could be developed into anti-UVB photoprotective sunscreens. Thus, this warrants further studies focusing on isolation and identifications of the bioactive compounds responsible for both its photoprotective and wound healing properties. A deeper study on mechanisms of the pathways that were affected by these compounds should be conducted as well to better understand this natural product and develop it into a potential cosmeceutical ingredient.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 28 Nov 2022 06:49
Last Modified: 26 Dec 2023 04:46
URI: http://repository.journal4submission.com/id/eprint/323

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