Recent Advances in Drug Toxicology-Metosartan Effect on Male Fertility

Metosartan has proved to be a effective drug against hypertension as it is a Angiotensin-Renin
cascade receptor blocker and also the β-receptor blocker and induces vasodilation of blood vessels in
heart through relaxation. Besides its positive effects the major disadvantage of the drug is its toxicity
on male reproductive organ testes. Drug effects the chromatin folding in testes and sperm whether its
effect is restricted to testes or globally is an interesting study now as it leads to genetic aberrations
leading to cancer and inherited diseases in next generation.