Hepatitis B Core IgM Detection in Neonates Born to HBsAg and HBeAg Positive Mothers in Maiduguri, Nigeria

Oyinloye, S. O. and Yusuf, M. and Yedak, E. S. and Oyebanji, J. (2019) Hepatitis B Core IgM Detection in Neonates Born to HBsAg and HBeAg Positive Mothers in Maiduguri, Nigeria. In: Emerging Research in Medical Sciences Vol. 2. B P International, pp. 69-75. ISBN Emerging Research in Medical Sciences Vol. 2

Full text not available from this repository.

Abstract

Hepatitis B virus is a serious global public health problem and is endemic in Africa, including Nigeria.
Infection of pregnant women during the second and third trimester poses a threat of 10 and 90%
respectively for vertical transmission. A total of ninety two blood samples from consenting pregnant
women were screened for HBsAg and HBeAg using ELISA kit (Cortez Diagnostic Inc, USA). Cord
blood samples collected from five neonates of women positive for HBsAg and HBeAg were screened
for HBcIgM using the same test kit. Questionnaire was used to collect data on demography, history of
blood transfusion and presence of tribal mark from the pregnant women. Overall prevalences of 8.7%
(8/92) and 5.4% (5/92) for HBsAg and HBeAg seromarkers, respectively were obtained. Mean age of
the pregnant women was 25.75 with 27.2% within 20–24 years and 28.3% within 25–29 years,
however this distribution was not statistically significant (p= 0.6840). Fifty percent (50%) of HBsAg
positive women were within the age group of 25–29 years while 80% of HBeAg positive women were
within the age group of 20 - 24 years. Blood transfusion (p= 0.002791) and tribal mark (p=0.00265)
were found to be associated with acquisition of the virus. Eighty percent (80%: 4/5) of the neonates
screened from HBsAg and HBeAg positive women were reactive for HBcIgM. The prevalence of
surface antigen in this study suggests the endemicity of hepatitis B virus in the study area while the
presence of both surface and envelope antigens in pregnant women portend infectivity. These results
suggest the utmost need for establishment of a sustainable intervention measure that would protect
not only pregnant women but women of childbearing age in order to mitigate spread of the virus.
Screening for other hepatitis B virus seromarkers besides HBsAg before blood transfusion is also
advocated.

Item Type: Book Section
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 16 Nov 2023 05:16
Last Modified: 16 Nov 2023 05:16
URI: http://repository.journal4submission.com/id/eprint/3258

Actions (login required)

View Item
View Item