Experimentally Histological Assessment for the Effect of Resveratrol in the Liver of Mice

Resveratrol a major Polyphenolic compound is a non-flavonoid stilbene, was isolated and purified as a first time in Iraq from the skin of black grape had grown in this country. Many studies confirmed the biological importance of this substance in different disorders, beside the protective properties specially towered the hepatic cells against free radicals and drugs toxic effects as histological level. In this study the purified resveratrol from Iraqi black grape was administered to groups of normal mice in three doses to investigate if there is any unwanted or harmful effects which may appear on the mice liver after fifteen days and thirty days administrated as intrapretoneal single dose a day Results showed that the extraction method estimated resveratrol in two stereo isomer mixture cis and trance forms. The different doses within two intervals affected the hepatocytes in different manner. The harmful properties of this substance appeared to be more potent in relation with dose and exposure time increasing. The study concluded that there must be an extensive studies that bridge the gap of available information with what is required regarding the Iraqi purified resveratrol as a safe therapeutic substance, not only for treating liver disorders, but in all it's therapeutic purposes