Determination of Hyperuricemia and its Associated Cardiovascular Risk Factors among Adult Yemeni People in Sana’a City, Yemen

This chapter aimed to investigate the prevalence of hyperuricemia in sample of Yemeni adult individual and its relationship to certain cardiovascular risk factors namely obesity, hypertension, serum glucose, total cholesterol, high serum triglyceride, Low High Density Lipoprotein (HDL-C) and high Low Density Lipoprotein (LDL-C). Hyperurecemia is metabolic problem that has become increasingly worldwide over the past several decades and it's the most risk factor for gout. Over the past few decades, hyperuricemia-a metabolic condition-has become more prevalent all over the world. It is more common in both developed and developing nations, such as Yemen. This was across sectional population based study conducted in Sana'a city for a period of 16 months from April 2017 to August 2018, a sample of 600 adult Yemeni people (275 male and 325 female aged ≥ 18 years) was randomly selected from those attending Al-Kuwait University Hospital and Consultation Clinic. All the study groups undergo full clinical history and examination includes measurement of BP and BMI, WC and the following laboratory investigation (FBS, Basal serum uric acid level, total cholesterol, serum TG, HDL and LDL).
The prevalence of hyperuricemia in this study was 8.8% (11.6% male and 6.4% female). The serum uric acid level in this study was significantly correlated with age, Waist Circumference (WC), SBP, DBP, FBS, T-cholesterol, TG and LDL but not with HDL. Elevation of the serum uric acid level has been known associated with major cardiovascular risk factors, such as hypertension, insulin resistance, dyslipidemia and obesity, which are hallmarks of metabolic syndrome. Furthermore, methods for the early identification, management, and prevention of hyperurecemia are desperately needed since they may help lower the risk of serious side effects such chronic kidney disease and cardiovascular disease.