The Great Escape: The Power of Cancer Stem Cells to Evade Programmed Cell Death

Castelli, Vanessa and Giordano, Antonio and Benedetti, Elisabetta and Giansanti, Francesco and Quintiliani, Massimiliano and Cimini, Annamaria and d’Angelo, Michele (2021) The Great Escape: The Power of Cancer Stem Cells to Evade Programmed Cell Death. Cancers, 13 (2). p. 328. ISSN 2072-6694

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Abstract

Cancer is one of the primary causes of death worldwide. Tumour malignancy is related to tumor heterogeneity, which has been suggested to be due to a small subpopulation of tumor cells named cancer stem cells (CSCs). CSCs exert a key role in metastasis development, tumor recurrence, and also epithelial–mesenchymal transition, apoptotic resistance, self-renewal, tumorigenesis, differentiation, and drug resistance. Several current therapies fail to eradicate tumors due to the ability of CSCs to escape different programmed cell deaths. Thus, developing CSC-selective and programmed death-inducing therapeutic approaches appears to be of primary importance. In this review, we discuss the main programmed cell death occurring in cancer and the promising CSC-targeting agents developed in recent years. Even if the reported studies are encouraging, further investigations are necessary to establish a combination of agents able to eradicate CSCs or inhibit their growth and proliferation.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 27 Feb 2023 06:36
Last Modified: 24 May 2024 05:32
URI: http://repository.journal4submission.com/id/eprint/523

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