In vivo and In vitro Antifungal Activity of 2,3-Dimethylquinoxline

Alfadil, Abdelbagi and Alsamhan, Hamoud A. and Ali, Ahmed S. and Alkreathy, Huda M. and Alrabia, Mohammad W. and Abdullah, Hani Y. (2021) In vivo and In vitro Antifungal Activity of 2,3-Dimethylquinoxline. Journal of Pharmaceutical Research International. pp. 198-207. ISSN 2456-9119

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Abstract

Aims: To explore the antifungal activity of 2,3-dimethylquinoxaline.

Study Design: A preclinical study of a compound against 10 fungal species.

Backgrounds: Severe fungal infections cause significant clinical problem and need more effort to search for new antifungals.

Methodology: We evaluated the susceptibility of 2,3-dimethylquinoxaline in vitro against a wide range of pathogenic fungi, including six Candida species, two Aspergillus species, one Cryptococcus species, and one Trichophyton species. Also, we evaluated the susceptibility of 2,3-dimethylquinoxaline in vivo against oral candidiasis using a mice model.

Results: The highest score of the minimum inhibitory concentration was 9 µg/ml against Cryptococcus neoformans. While, the lowest score was 1125 µg/ml against Candida tropicalis. The oral candidiasis in a mouse model was resolved using 2,3-dimethylquinoxaline 1% gel.

Conclusion: The 2,3-Dimethyquinoxaline has interesting antifungal activity. Quinoxalines in general need to be further developed as a promising antifungal candidate.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 24 Feb 2023 05:53
Last Modified: 01 Jan 2024 12:45
URI: http://repository.journal4submission.com/id/eprint/626

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