The Role of Alpha-Lactalbumin with Myoinositol in the Treatment of PCOS: A Review

Polycystic Ovary Syndrome (PCOS) presents commonly in women of reproductive age group, and has a multifactorial pathogenesis involving insulin resistance and androgen excess, influenced by obesity, diet, lifestyle, metabolic factors, stress, and environmental factors. Inositols (myoinositol-MI, D-chiro inositol-DCI) are part of the therapy options to address insulin resistance in PCOS. However, many women may be inositol nonresponsive due to competitive reduction of inositol intestinal absorption, gut dysbiosis and chronic inflammation. Addition of alpha-lactalbumin can help increase intestinal absorption of inositols, as well as improve gut dysbiosis and inflammation, along with reducing insulin resistance. Presented here is a review of studies that have shown improved rates of ovulation, MI absorption and levels, as well as metabolic and hormonal parameters, when alpha-lactalbumin is added to myoinositol.