Preoperative Radiosurgery in Management of Brain Metastases

Topkan, Erkan and Kucuk, Ahmet and Senyurek, Sukran and Sezen, Duygu and Durankus, Nulifer Kilic and Akdemir, Eyub Yasar and Ikiz, Esma Didem and Bolukbasi, Yasemin and Pehlivan, Berrin and Selek, Ugur (2020) Preoperative Radiosurgery in Management of Brain Metastases. Journal of Cancer and Tumor International, 10 (1). pp. 1-11. ISSN 2454-7360

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Abstract

Brain metastases (BMs), the most frequent intracranial tumors, are diagnosed in approximately 30% of all adult patients over the span of planned treatment against a broad spectrum of solid cancers. The prognosis of patients presenting with BM is bleak with an expected median OS of only 4-7 months. However, some particular patients’ groups may enjoy longer survival durations with effective systemic and local therapies. At present, the feasible alternatives for active management of BMs typically include the whole-brain radiotherapy (WBRT), surgery, definitive SRS, postoperative SRS, systemic chemotherapy, targeted therapies, and their combination variants. Considering the local treatment, the severe neurotoxic effects of WBRT, and the increased risk for radionecrosis and leptomeningeal dissemination after postoperative SRS and together with the ineligibility of certain patients during the postoperative period prompted the energetic quest of alternative treatment strategies for such patients. In this respect, the novel preoperative SRS (PO-SRS) was proposed to provide at least equivalent local control rates with lesser radionecrosis and leptomeningeal dissemination risk. Respecting the scarcity of related literature, the present review aimed to meticulously detail theplausible rationale and accessible evidence for the novel PO-SRS in the management of patients presenting with BMs.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 25 Feb 2023 08:23
Last Modified: 09 Jul 2024 06:53
URI: http://repository.journal4submission.com/id/eprint/849

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