Interference of Recreational Intake of 1, 3, 7-Trimethylxanthine on Sensorimotor, Cognitive Functions and Fasting Blood Glucose in Wistar Rats

Robinson, Bright Chisozum and Chuemere, Arthur Nwafor and Chinko, Bruno Chukwuemeka and Ukoro, Blessing (2023) Interference of Recreational Intake of 1, 3, 7-Trimethylxanthine on Sensorimotor, Cognitive Functions and Fasting Blood Glucose in Wistar Rats. Asian Journal of Research and Reports in Neurology, 6 (1). pp. 103-110.

[thumbnail of Ukoro612023AJORRIN105355.pdf] Text
Ukoro612023AJORRIN105355.pdf - Published Version

Download (630kB)

Abstract

1, 3, 7-Trimethylxanthine (Caffeine) is a natural alkaloid found in coffee beans, tea leaves, cocoa beans, cola nut etc. It is probably the most frequently ingested pharmacologically active substance in the world at large. This study was carried out to evaluate the effects of recreational intake of caffeine (methyl-xanthine) on sensorimotor and cognitomotor functions and fasting blood glucose in rat model. In this study, a total of twenty (20) wistar rats were randomly divided into 4 groups. After three (3) weeks of acclimatization, caffeine was administered to the rats as follows; Group1 (control) received normal water, group 2 was treated with 0.4g/ml of caffeine, group3 – 0.8g/ml of caffeine, and group4 – 1.6g/ml of caffeine, all for a period of thirty (30) days. Opaque maze (memory), elevated maze (intelligent and anxiety), beam walking (learning) and swimming/climbing test (learning), were used to evaluate sensory, motor, and cognitive performances of the rats in both control group and treated groups. Also glucometer with fine test strips was used to determine the blood glucose level of the rats at day 1, day 5, day 10, 21 and 30 during the period of caffeine administration. Data was obtained and inferentially analysed using ANOVA (SPSS version 23). The result from this study showed that caffeine significantly (p < 0.05) interfered negatively with cognitive performance in the group treated with 1.6g/ml of caffeine and also significantly decreased blood glucose level in low dose treated group and increase blood glucose at higher doses. In conclusion, Caffeine was found to improve sustained cognitive functions at medium doses (0.8g/ml), sustained motor steadiness at low (0.4g/ml) and moderate doses (0.8g/ml) but at higher doses produced uncoordinated movement.

Item Type: Article
Subjects: Journal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 13 Oct 2023 09:30
Last Modified: 13 Oct 2023 09:30
URI: http://repository.journal4submission.com/id/eprint/2847

Actions (login required)

View Item
View Item