Mechanisms of the Aqueous Solvolysis of the Ring-opening of the Lactone Ring of Goniodomin A

Jr., B. Andes Hess and Smentek, Lidia (2022) Mechanisms of the Aqueous Solvolysis of the Ring-opening of the Lactone Ring of Goniodomin A. International Research Journal of Pure and Applied Chemistry, 23 (6). pp. 9-16. ISSN 2231-3443

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Abstract

The phycotoxin Goniodomin A is a Dinoflagellate of the Alexandrium genus and is a macrocyclic lactone. It is found widely in sea water and is known to open slowly the lactone in water. The cleavage of the lactone is sensitive to the pH of the water. As one changes the pH from ~6 to 8 its solvolytic rate dramatically increases. Treatment of kinetic data previously published indicates that there are two competing first-order reactions, an SN­1 and an intramolecular SN2, which is a pseudo first-order reaction.

Item Type: Article
Subjects: Journal Eprints > Chemical Science
Depositing User: Managing Editor
Date Deposited: 20 Dec 2022 05:21
Last Modified: 02 Apr 2024 04:17
URI: http://repository.journal4submission.com/id/eprint/445

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